The following documents and presentations are available to help people learn and understand the variant curation process, as well as ClinGen's efforts to modify ACMG variant assessment criteria. For questions about existing materials or requests for new materials, contact us at clingen@clinicalgenome.org.


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SVI General Recommendations for Using ACMG/AMP Criteria

SVI provides general recommendations for using the ACMG/AMP criteria to improve consistency in usage and transparency in classification rationale.


ViewBA1 Exception List

Supporting Documents - July 30, 2018

ViewStandards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.

Supporting Documents - May 17, 2017 - The American College of Medical Genetics and Genomics (ACMG) previously developed guidance for the interpretation of sequence variants.